Desktop DDR4 is currently supported by only one platform, of course: Intel X99 Wellsburg chipset with a Haswell-E processor. Most X99 mobos have 8 physical DIMM slots, some have 4, 12, even 16. Most can address 64GB, some only 32GB and others up to 128GB or more. There basically are no low-grade cheap X99 mobos, they're all excellent, they're all robustly overengineered (and overpriced) for enthusiasts.
My question is: can I combine two identical 4x8GB(DS) DDR4-3000 15-15-15-35 1.35V kits (G.Skill F4-3000C15Q-32GRK x 2)? And yes, 64GB is excessive, but I often run virtual machines and processes which actively leverage more cores/threads and RAM (plus I typically allocate a RAM Disk), and my 32GB does bottleneck. Indeed, addressing too much RAM can actually slow performance down if all you do is gaming. But I do far more than just gaming and I want the fastest 64GB I can get.
I realize that many people combine mismatched kits to save money, and many select incorrect parts based on price rather than being carefully about compatibilities and timings. My focus is more on performance than price - factory-matched 8x8GB DDR4 kits are available, but the fastest of these (that I could find) is DDR4-2800 15-16-16-35. My understanding is that factory memory profiles (especially among the dozens of tertiary timings) can vary between "identically matched" kits, and - worse! - that timings are already restrictive and rated in isolation from other onboard memory.
And I realize that 3000MHz is a fairly extreme DRAM frequency (the highest available is 3333MHz, perhaps 3400MHz, but at even higher cost and only at lesser 4x4GB capacities). And I may be forced to balance underspec XMP speeds against processor speeds, especially if I push an aggressive overclock.
But can matched sets of DDR4 be installed with a not-too-unreasonable expectation of it just working (like DDR3 usually does)? Or can all 64GB be made to work through some tweaking of timings, even if they need to be loosened up or throttled down a bit? Or is the entire idea a simply incompatible fail just asking for headaches? (I have an Asus R5E mobo and i7-5960X, if that matters.)
I could find no (believable) online data from people attempting to do this. I'm kinda looking at you enterprise pro/IT guys for a better answer (or at least for a better-informed guess). DDR4 RDIMMs have already been around for a while, I notice, and can't be all that different (in terms of basic technical limits) than their DDR4 UDIMM counterparts.