if you have firewall and antivirus you don't need it,
Plus Tech guru i beleave tested it, the annoyiances dosen't check the file, it checks the name, and if its in the registry, if you have setup for say firefox, it will compain and ask permission, rename it to say "Francis work.exe" it won't ask, so its not that good anyway.
Plus you wern't worring about XP were you? considering that XP didn't have this tool, so why worrie about turning it off, you lived without it in XP/2K/9x