To put it bluntly, no.Originally Posted by Greco101
First, settle on a board. My recommends out of this thread would be the Striker Extreme or the eVGA 680i SLI (what Redundant linked). Both are very similar, the eVGA just being less exspensive.
Next, you need to decide on your RAM? I like the Flex better than the Reaper. Just my opinion though.
Your going to watercool? Then don't even worry about the mini discussion about heatsinks... You'll be fine with either board then.
As long as your careful, patient, and keep a good temper during the build, it will be as close to painless as it'll get.